Cascade radical cyclisations leading to polycyclic diterpenes.: Total synthesis of (±)-spongian-16-one

被引：45

作者：

Pattenden, G ^{[1
]}

Roberts, L ^{[1
]}

Blake, AJ ^{[1
]}

机构：

[1] Univ Nottingham, Dept Chem, Nottingham NG7 2RD, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 05期

关键词：

D O I：

10.1039/a708042e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cascade of three consecutive 6-endo-trig radical cyclisations from the polyene acyl radical intermediate 12 derived from the selenoate 11 is used to construct the trans,anti,trans,anti,cis-tetracyclic keto lactone 20 in one step. Manipulation of the ketone function in 20 to the corresponding gem-dimethyl substituted carbon then completed a concise synthesis of the marine metabolite spongian-16-one 1.

引用

页码：863 / 868

页数：6

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