Enzymatic resolution of (RS)-p-hydroxy selenides in organic media

被引：23

作者：

Costa, CE

Clososki, GC

Barchesi, HB

Zanotto, SP

Nascimento, MG

Comasseto, JV

机构：

[1] Univ Sao Paulo, Inst Quim, BR-05599070 Sao Paulo, SP, Brazil

[2] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 24期

关键词：

D O I：

10.1016/j.tetasy.2004.11.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Kinetic resolutions of a number of beta-hydroxy selenides promoted by enzymes were performed using PPL (free Porcine pancreatic lipase), PSL (Amano PS-free Pseudomonas sp. lipase) and CALB (NOVOZYM 435(R)-immobilized Candida Antarctica lipase type B) with (RS)-1-phenylselanyl-propan-2-ol. CALB gave the best results and provided both (R)- and (S)-enantiomers in high enantiomeric purity. A comparative study of the effect of temperature, solvent, enzyme immobilization and the structure of the substrates on the resolution is presented. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：3945 / 3954

页数：10

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