Analysis of the relationship between PPAR-γ2 gene variants and severe insulin resistance in obese patients with impaired glucose tolerance

被引:27
作者
Blüher, M [1 ]
Paschke, R [1 ]
机构
[1] Univ Leipzig, Fac Med, Dept Med 3, D-04103 Leipzig, Germany
关键词
PPAR-gamma; 2; Pro115 Gln variant; insulin resistance; impaired glucose tolerance; ACTIVATED RECEPTOR-GAMMA-2 GENE; BODY-MASS INDEX; PPAR-GAMMA; PRO12ALA VARIANT; POLYMORPHISM; SENSITIVITY; MUTATIONS; REGULATOR;
D O I
10.1055/s-2003-39235
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Mutations in the peroxisome proliferator-activated receptor-gamma 2 (PPAR-gamma2) gene may cause obesity and insulin resistance. Therefore we investigated whether known variants in the PPAR-I 2 gene are associated with obesity and extreme insulin resistance in obese patients with impaired glucose tolerance (IGT). The Pro115Gln, Pro12Ala, Pro467Leu, Va1290Met and a silent polymorphism C478 T were examined in 48 subjects with IGT and insulin resistance (IR), characterized by euglycemic hyperinsulinemic clamps, and in 52 healthy insulin sensitive (IS) controls. We found one proband in the IR group with the Pro115Gln variant. This subject showed a lower whole body glucose uptake (18 mumol/kg per min) compared to the entire IR group (29 mumol/kg per min). The body weight of the proband (BMI 28.5 kg/m(2)) was within the average of the IR group (30.3 +/- 0.8 kg/m(2)). The Pro12Ala variant was not associated with differences in BMI, in the degree of insulin resistance between the IR and IS group. The Pro467Leu, Va1290Met mutations and the silent polymorphism CAC478CAT were not detected in any group. In conclusion, the Pro115Gln variant, but not the Pro12Ala mutation in the PPAR-gamma2 gene, could be a rare cause of severe insulin resistance.
引用
收藏
页码:85 / 90
页数:6
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