Mild cognitive impairment -: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease?

被引：474

作者：

Chételat, G

Desgranges, B

de la Sayette, V

Viader, F

Eustache, F

Baron, JC

机构：

[1] Univ Caen, Cyceron PET Ctr, INSERM, EO 218, F-14032 Caen, France

[2] Univ Paris 05, CNRS, UMR 8581, EPHE, F-75270 Paris, France

[3] CHU Caen, Serv Neurol Vastel, Caen, France

[4] Univ Cambridge, Dept Neurol, Cambridge CB2 1TN, England

来源：

NEUROLOGY | 2003年 / 60卷 / 08期

关键词：

D O I：

10.1212/01.WNL.0000055847.17752.E6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Patients with mild cognitive impairment (MCI) were assessed, and a metabolic profile associated with conversion to AD at 18-month follow-up was sought. As compared with nonconverters (n = 10), converters (n = 7) had lower fluorodeoxyglucose uptake in the right temporoparietal cortex (p = 0.02, corrected for cluster size), without individual overlap. Awaiting replication in an independent sample, these findings suggest that among patients with MCI, fluorodeoxyglucose PET may accurately identify rapid converters.

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页码：1374 / 1377

页数：4

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