Catalytic enantioselective alkynylation of prochiral sp3 C-H bonds adjacent to a nitrogen atom

被引：339

作者：

Li, ZP ^{[1
]}

Li, CJ ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 26期

关键词：

D O I：

10.1021/ol047814v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The construction of chiral carbon centers via the first catalytic asymmetric alkynylation of prochiral CH2 groups was developed by using a copper-catalyzed double activation of sp(3) and sp C-H bonds. Optically active 1-alkynylated tetrahydroisoquinolines were obtained by this method.

引用

页码：4997 / 4999

页数：3

共 27 条

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