Bipolar illness

被引:4
作者
ElMallakh, RS
机构
[1] Mood Disorders Research Program, Dept. of Psychiat. and Behav. Sci., Univ. of Louisville Sch. of Medicine, Louisville, KY
[2] University of Louisville, School of Medicine, Dept. of Psychiat. and Behav. Sci., Louisville
关键词
D O I
10.1097/00007611-199708000-00002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. Within the past 5 years, several factors have altered our view of the diagnosis, prognosis, treatment, and genetics of bipolar illness. Methods. Significant advances in these areas are reviewed. Results. Diagnostic changes include establishment of symptom duration requirements that limit confusion with affective instability. Prognostic insights include the realization that illness likely begets illness and, conversely, that adequate control is probably instrumental in improving long-term prognosis. Therapeutic advances are marked by the Food and Drug Administration approval of divalproex for acute mania. Conclusions. Genetic and family studies suggest that (1) bipolar illness is a discrete condition, not related to unipolar depression; and (2) bipolar illness may manifest a phenomenon known as anticipation (worsening of the disease with succession generations), which may be related to a specific nucleic acid abnormality.
引用
收藏
页码:775 / 779
页数:5
相关论文
共 67 条
[1]  
AKISKAL HS, 1985, J CLIN PSYCHIAT, V46, P41
[2]  
AKISKAL HS, 1987, PSYCHOPHARMACOL BULL, V23, P68
[3]  
ANGST J, 1987, PSYCHOPHARMACOL BULL, V23, P66
[5]  
[Anonymous], 1994, Am J Psychiatry, V151, P1
[6]  
BERRETTINI WH, 1991, PSYCHIAT GENET, V2, P191
[7]  
Bolton S, 1996, AM J PSYCHIAT, V153, P1202
[8]   The efficacy of 2 different dosages of methylphenidate in treating adults with attention-deficit hyperactivity disorder [J].
Bouffard, R ;
Hechtman, L ;
Minde, K ;
Iaboni-Kassab, F .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2003, 48 (08) :546-554
[9]   EFFICACY OF DIVALPROEX VS LITHIUM AND PLACEBO IN THE TREATMENT OF MANIA [J].
BOWDEN, CL ;
BRUGGER, AM ;
SWANN, AC ;
CALABRESE, JR ;
JANICAK, PG ;
PETTY, F ;
DILSAVER, SC ;
DAVIS, JM ;
RUSH, AJ ;
SMALL, JG ;
GARZATREVINO, ES ;
RISCH, SC ;
GOODNICK, PJ ;
MORRIS, DD .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (12) :918-924
[10]   THE CLINICAL APPROACH TO THE DIFFERENTIAL-DIAGNOSIS OF BIPOLAR DISORDER [J].
BOWDEN, CL .
PSYCHIATRIC ANNALS, 1993, 23 (02) :57-63