Effects of voltage trajectory on action potential voltage threshold in simulations of cat spinal motoneurons

被引：7

作者：

Dai, Y ^{[1
]}

Jones, KE ^{[1
]}

Fedirchuk, B ^{[1
]}

Jordan, LM ^{[1
]}

机构：

[1] Univ Manitoba, Dept Physiol, Winnipeg, MB R3E 3J7, Canada

来源：

NEUROCOMPUTING | 2000年 / 32卷

关键词：

voltage threshold; spike initiation; fictive locomotion; computer simulation;

D O I：

10.1016/S0925-2312(00)00150-8

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

A single-cell neuronal model was used to investigate the effect of membrane trajectory on voltage threshold (V-th) for action potential generation. Previous results suggested that hyperpolarization of V-th could be produced by a rapid membrane depolarization, but this effect is limited to the first spike in a train. This study shows rapid current injections hyperpolarize V-th because they are more effective in activating the sodium current underlying spiking. The hyperpolarization of V-th induced by rapid membrane depolarization becomes less effective in altering V-th when other mechanisms of enhancing the fast sodium current underlying action potentials are activated. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

引用

页码：105 / 111

页数：7