Signal transduction and activation of the NADPH oxidase in eosinophils

被引：7

作者：

Lindsay, MA ^{[1
]}

Giembycz, MA ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Med, Natl Heart & Lung Inst, London SW3 6LY, England

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 1997年 / 92卷

关键词：

leukotriene B-4; eosinophil; NADPH oxidase; signal transduction;

D O I：

10.1590/S0074-02761997000800016

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Activation of the eosinophil NADPH oxidase and the subsequent release of toxic oxygen radicals has been implicated in the mechanism of parasite killing and inflammation. At present, little is known of the signal transduction pathway that govern agonist-induced activation of the respiratory burst and is the subject of this review In particular, we focus an the ability of leukotrine B-4 to activate the NADPH oxidase in guinea-pig peritoneal eosinophils which cart be obtained in sufficient number and purity for detailed biochemical experiments to be performed.

引用

页码：115 / 123

页数：9

共 85 条

[1] NANOMOLAR ARACHIDONIC-ACID INFLUENCES THE RESPIRATORY BURST IN EOSINOPHILS AND NEUTROPHILS INDUCED BY GTP-BINDING PROTEIN - A COMPARATIVE-STUDY OF THE RESPIRATORY BURST IN BOVINE EOSINOPHILS AND NEUTROPHILS [J].

AEBISCHER, CP ;

PASCHE, I ;

JORG, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 218 (02) :669-677

[2] PD-098059 IS A SPECIFIC INHIBITOR OF THE ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE IN-VITRO AND IN-VIVO [J].

ALESSI, DR ;

CUENDA, A ;

COHEN, P ;

DUDLEY, DT ;

SALTIEL, AR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (46) :27489-27494

[3] PROTEIN-KINASE C-INDEPENDENT ACTIVATION OF RAF-1 AND MITOGEN-ACTIVATED PROTEIN-KINASE BY LEUKOTRIENE B-4 IN GUINEA-PIG EOSINOPHILS [J].

ARAKI, R ;

KOMADA, T ;

NAKATANI, K ;

NAKA, M ;

SHIMA, T ;

TANAKA, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 210 (03) :837-843

[4] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT [J].

BABIOR, BM ;

KIPNES, RS ;

CURNUTTE, JT .

JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (03) :741-744

[5]

BADWEY JA, 1984, J BIOL CHEM, V259, P7870

[6]

BARNETTE MS, 1995, J PHARMACOL EXP THER, V273, P674

[7]

Bates ME, 1996, J IMMUNOL, V156, P711

[8] Interplay between Ras-related and heterotrimeric GTP binding proteins: Lifestyles of the BIG and little [J].

Bokoch, GM .

FASEB JOURNAL, 1996, 10 (11) :1290-1295

[9] REGULATION OF THE HUMAN NEUTROPHIL NADPH OXIDASE BY THE RAC GTP-BINDING PROTEINS [J].

BOKOCH, GM .

CURRENT OPINION IN CELL BIOLOGY, 1994, 6 (02) :212-218

[10] CHEMOATTRACTANT SIGNALING AND LEUKOCYTE ACTIVATION [J].

BOKOCH, GM .

BLOOD, 1995, 86 (05) :1649-1660

← 1 2 3 4 5 6 7 8 9 →