Artemisinins: mechanisms of action and potential for resistance

被引：153

作者：

Krishna, S

Uhlemann, AC

Haynes, RK

机构：

[1] St George Hosp, Sch Med, Dept Cellular & Mol Med Infect Dis, London SW17 0RE, England

[2] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China

来源：

DRUG RESISTANCE UPDATES | 2004年 / 7卷 / 4-5期

基金：

英国惠康基金;

关键词：

Plasmodium falciparum; malaria; artemisinin; endoperoxides;

D O I：

10.1016/j.drup.2004.07.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Artemisinins form the most important class of antimalarial currently available, particularly because they are effective against parasites resistant to almost all the other classes. Their mechanism of action is controversial. Some aspects of this controversy are reviewed here. Whilst there is no clinical resistance yet identified to artemisinins, the potential to examine the relationship between polymorphisms in PfATP6 (a target of artemisinins) in multidrug resistant isolates of Plasmodium falciparum, is also discussed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：233 / 244

页数：12

相关论文

共 107 条

[1]

Adjuik M, 2004, LANCET, V363, P9, DOI 10.1016/S0140-6736(03)15162-8

[2] Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children:: a randomised, multicentre trial [J].

Adjuik, M ;

Agnamey, P ;

Babiker, A ;

Borrmann, S ;

Brasseur, P ;

Cisse, M ;

Cobelens, F ;

Diallo, S ;

Faucher, JF ;

Garner, P ;

Gikunda, S ;

Kremsner, PG ;

Krishna, S ;

Lell, B ;

Loolpapit, M ;

Matsiegui, PB ;

Missinou, MA ;

Mwanza, J ;

Ntoumi, F ;

Olliaro, P ;

Osimbo, P ;

Rezbach, P ;

Some, E ;

Taylor, WRJ .

LANCET, 2002, 359 (9315) :1365-1372

[3] Glucose and lactate kinetics in children with severe malaria [J].

Agbenyega, T ;

Angus, BJ ;

Bedu-Addo, G ;

Baffoe-Bonnie, B ;

Guyton, T ;

Stacpoole, PW ;

Krishna, S .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (04) :1569-1576

[4] Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients [J].

Alin, MH ;

Ashton, M ;

Kihamia, CM ;

Mtey, GJB ;

Bjorkman, A .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1996, 90 (01) :61-65

[5]

Ando W, 1992, ORGANIC PEROXIDES, P295

[6] In vivo removal of malaria parasites from red blood cells without their destruction in acute falciparum malaria [J].

Angus, BJ ;

Chotivanich, K ;

Udomsangpetch, R ;

White, NJ .

BLOOD, 1997, 90 (05) :2037-2040

[7]

[Anonymous], 1979, CHINESE MED J-PEKING, V92, P811

[8] REACTION OF ANTIMALARIAL ENDOPEROXIDES WITH SPECIFIC PARASITE PROTEINS [J].

ASAWAMAHASAKDA, W ;

ITTARAT, I ;

PU, YM ;

ZIFFER, H ;

MESHNICK, SR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (08) :1854-1858

[9] STRUCTURE-ACTIVITY-RELATIONSHIPS OF THE ANTIMALARIAL AGENT ARTEMISININ .1. SYNTHESIS AND COMPARATIVE MOLECULAR-FIELD ANALYSIS OF C-9 ANALOGS OF ARTEMISININ AND 10-DEOXOARTEMISININ [J].

AVERY, MA ;

GAO, FG ;

CHONG, WKM ;

MEHROTRA, S ;

MILHOUS, WK .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (26) :4264-4275

[10] Structure-activity relationships of the antimalarial agent artemisinin .5. Analogs of 10-deoxoartemisinin substituted at C-3 and C-9 [J].

Avery, MA ;

Mehrotra, S ;

Johnson, TL ;

Bonk, JD ;

Vroman, JA ;

Miller, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (21) :4149-4155

← 1 2 3 4 5 6 7 8 9 10 →