Binding and activation of human plasminogen by Mycobacterium tuberculosis

被引：21

作者：

Monroy, V

Amador, A

Ruiz, B

Espinoza-Cueto, P

Xolalpa, W

Mancilla, R

Espitia, C

机构：

[1] Natl Autonomous Univ Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City 04510, DF, Mexico

[2] Natl Autonomous Univ Mexico, Inst Invest Biomed, Dept Biol Mol, Mexico City 04510, DF, Mexico

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 07期

关键词：

D O I：

10.1128/IAI.68.7.4327-4330.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The first evidence of the interaction of Mycobacterium tuberculosis with the plasminogen system is herein reported. By FACScan analysis and affinity blotting, lysine-dependent binding of plasminogen to M. tuberculosis was demonstrated. The binding molecules were 30-, 60-, and 66-kDa proteins present in cell wall and soluble protein extracts. The activation of plasminogen, which occurred only in presence of fibrin and was not inhibited by the host serpin, alpha(2)-antiplasmin, was also demonstrated.

引用

页码：4327 / 4330

页数：4

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