Analysis of urinary nucleosides.: III.: Identification of 5′-deoxycytidine in urine of a patient with head and neck cancer

被引：30

作者：

Dudley, E

Lemiere, F

Van Dongen, W

Langridge, JI

El-Sharkawi, S

Games, DE

Esmans, EL

Newton, RP

机构：

[1] Univ Coll Swansea, Sch Biol Sci, Biochem Grp, Swansea SA2 8PP, W Glam, Wales

[2] Univ Antwerp, RUCA, UIA,Dept Chem, Nucleoside & Mass Spectrometry Res Unit, B-2020 Antwerp, Belgium

[3] Singleton Hosp Trust, Oncol Unit, Swansea SA2 8QA, W Glam, Wales

[4] Univ Coll Swansea, Dept Chem, Mass Spectrometry Res Unit, Swansea SA2 8PP, W Glam, Wales

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2003年 / 17卷 / 11期

关键词：

D O I：

10.1002/rcm.1034

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Modified nucleosides in the urine have been postulated to be diagnostic indices of disease, particularly of cancer. The urine of a patient with terminal head and neck cancer has been found to contain a modified nucleoside with a protonated molecule of m/z 228. By means of high-performance liquid chromatography/ion trap mass spectrometry (HPLC/ITMS) and capillary liquid chromatography/triple quadruple mass spectrometry (CapLC/TQMS) we have identified the compound as 5'-deoxycytidine. This is the first report of 5-deoxycytidine in man: in addition to the elucidation of its structure, its possible origins and the potential significance of its occurrence are discussed. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：1132 / 1136

页数：5

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