Investigation of the in vitro metabolism of 17β-estradiol by LC-MS/MS using ESI and APCI

被引：13

作者：

Rathahao, E ^{[1
]}

Hillenweck, A ^{[1
]}

Paris, A ^{[1
]}

Debrauwer, L ^{[1
]}

机构：

[1] INRA, Lab Xenobiot, F-31931 Toulouse 9, France

来源：

ANALUSIS | 2000年 / 28卷 / 04期

关键词：

D O I：

10.1051/analusis:2000280273

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

of Liquid chromatography coupled to tandem mass spectrometry with electrospray ionisation (ESI) and atmospheric pressure chemical ionisation (APCI) were used for the investigation of the in vitro metabolism of 17 beta-estradiol on rat isolated hepatocytes. The catechol estrogens corresponding to 17 beta-estradiol and estrone were identified by ESI, together with their glutathione and glucuronide conjugates, whereas more apolar compounds such as methoxylated catechol estrogens were characterised using APCI.

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页码：273 / 279

页数：7

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