Novel anti-glycation therapeutic agents: glyoxalase I mimetics

被引：13

作者：

Battah, S ^{[1
]}

Ahmed, N ^{[1
]}

Thornalley, PJ ^{[1
]}

机构：

[1] Univ Essex, Dept Sci Biol, Colchester CO4 3SQ, Essex, England

来源：

MAILLARD REACTION IN FOOD CHEMISTRY AND MEDICAL SCIENCE: UPDATE FOR THE POSTGENOMIC ERA | 2002年 / 1245卷

关键词：

glyoxalase; histidine; carnosine; methylglyoxal; glycation;

D O I：

10.1016/S0531-5131(02)00884-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glyoxalase I mimetic activity has been associated with the imidazole function. Histidine, histidine methyl ester and carnosine had glyoxalase I mimetic activity under physiological conditions. Carnosine scavenged methylglyoxal to form beta-alanyl-N-DL-lactoyl-L-histidine (lactoyl-camosine). This scavenging of alpha-oxoaldehydes by carnosine, and hydrolysis of the adduct formed to the corresponding aldonic acid catalysed by acyl-histidine hydrolase, represented a glyoxalase system mimetic activity. Glyoxalase mimetics are novel anti-glycation agents that may have therapeutic applications. Their specific activity, however, needs to be improved to have significant pharmacological effect. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：107 / 111

页数：5

共 15 条

[1] CLELLAND JD, 1991, J CHEM SOC P1, V1, P3009
[2] GLYOXALASE-I ENZYME STUDIES .4. GENERAL BASE-CATALYZED ENEDIOL PROTON-TRANSFER REARRANGEMENT OF "METHYL-GLYOXALGLUTATHIONYLHEMITHIOL AND PHENYLGLYOXALGLUTATHIONYLHEMITHIOL ACETAL TO S-LACTOYL-GLUTATHIONE AND S-MANDELOYLGLUTATHIONE FOLLOWED BY HYDROLYSIS - MODEL FOR GLYOXALASE ENZYME-SYSTEM
HALL, SS
DOWEYKO, AM
JORDAN, F
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (18) : 5934 - 5939
[3] Carnosine protects proteins against methylglyoxal-mediated modifications
Hipkiss, AR
Chana, H
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 248 (01) : 28 - 32
[4] KOOP DR, 1985, J BIOL CHEM, V260, P3607
[5] ALPHA-HYDROXYALDEHYDES, PRODUCTS OF LIPID-PEROXIDATION
LOIDLSTAHLHOFEN, A
SPITELLER, G
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1994, 1211 (02): : 156 - 160
[6] THE METABOLISM OF AMINOACETONE TO METHYLGLYOXAL BY SEMICARBAZIDE-SENSITIVE AMINE OXIDASE IN HUMAN UMBILICAL ARTERY
LYLES, GA
CHALMERS, J
[J]. BIOCHEMICAL PHARMACOLOGY, 1992, 43 (07) : 1409 - 1414
[7] Mann VM, 1999, KIDNEY INT, V55, P2582
[8] GLYOXALASE SYSTEM IN CLINICAL DIABETES-MELLITUS AND CORRELATION WITH DIABETIC COMPLICATIONS
MCLELLAN, AC
THORNALLEY, PJ
BENN, J
SONKSEN, PH
[J]. CLINICAL SCIENCE, 1994, 87 (01) : 21 - 29
[9] SAMPLE STORAGE-CONDITIONS FOR THE ASSAY OF GLYOXALASE ACTIVITIES IN WHOLE-BLOOD SAMPLES
MCLELLAN, AC
THORNALLEY, PJ
[J]. ANNALS OF CLINICAL BIOCHEMISTRY, 1992, 29 : 222 - 223
[10] THE FORMATION OF METHYLGLYOXAL FROM TRIOSE PHOSPHATES - INVESTIGATION USING A SPECIFIC ASSAY FOR METHYLGLYOXAL
PHILLIPS, SA
THORNALLEY, PJ
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 212 (01): : 101 - 105

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