TRPM channels, calcium and redox sensors during innate immune responses

被引：77

作者：

Massullo, Pam

Sumoza-Toledo, Adriana

Bhagat, Harivadan

Partida-Sanchez, Santiago

机构：

[1] Ohio State Univ, Coll Med, Columbus Childrens Res Hosp, Columbus, OH 43205 USA

[2] Ohio State Univ, Mol Cellular & Dev Biol Program, Columbus, OH 43210 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2006年 / 17卷 / 06期

关键词：

TRPM ion channels; ADP-ribose; CD38; oxidative stress; inflammation;

D O I：

10.1016/j.semcdb.2006.11.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Melastatin-related TRPM ion channels have emerged as novel therapeutic targets due to their potential ability to modulate the function and fate of immune cells during inflammation, innate, and adaptive immunity. Four family members, TRPM I, TRPM2, TRPM4 and TRPM7 have a strong presence in the immune system. TRPM channels regulate ion-homeostasis by sensing cellular redox status and cytoplasmic calcium levels. TRPM2 for example, is highly expressed in phagocytes. This channel is activated by intracellular ADP-ribose upon exposure to oxidative stress and induces cell death. Here we will review the functional links between TRPM-mediated ion conductance, chemotaxis, apoptosis, and innate immunity. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：654 / 666

页数：13

共 133 条

[1] A key role for TRPM7 channels in anoxic neuronal death [J].