Coordinated Chromatin Control: Structural and Functional Linkage of DNA and Histone Methylation

被引：157

作者：

Cheng, Xiaodong ^{[1
]}

Blumenthal, Robert M. ^{[2
,3
]}

机构：

[1] Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

[2] Univ Toledo Hlth Sci Campus, Program Bioinformat & Proteom Genom, Toledo, OH 43614 USA

[3] Univ Toledo Hlth Sci Campus, Dept Med Microbiol & Immunol, Toledo, OH 43614 USA

来源：

BIOCHEMISTRY | 2010年 / 49卷 / 14期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

DE-NOVO METHYLATION; MAMMALIAN DNA; LYSINE METHYLATION; DEMETHYLASE LSD1; CXXC DOMAIN; SRA DOMAIN; METHYLTRANSFERASE COMPLEX; SUBSTRATE-SPECIFICITY; CYTOSINE METHYLATION; H3K4; METHYLATION;

D O I：

10.1021/bi100213t

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One of the most fundamental questions in the control of gene expression in mammals is how epigenetic methylation patterns of DNA and histories are established, erased, and recognized. This central process in controlling metazoan gene expression includes coordinated covalent modifications of DNA and its associated histones. This review focuses on recent developments in characterizing the functional links between the methylation status of the DNA and of two particularly important histone marks. Mammalian DNA methylation is intricately connected to the presence of unmodified lysine 4 and methylated lysine 9 residues in histone H3. An interconnected network of methyltransferases, demethylases, and accessory proteins is responsible for changing or maintaining the modification status of specific regions of chromatin. The structural and functional interactions among members of this network are critical to processes that include imprinting and differentiation, dysregulation of which is associated with disorders ranging from inflammation to cancer.

引用

页码：2999 / 3008

页数：10

共 168 条

[1] The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression [J].

Achour, M. ;

Jacq, X. ;

Ronde, P. ;

Alhosin, M. ;

Charlot, C. ;

Chataigneau, T. ;

Jeanblanc, M. ;

Macaluso, M. ;

Giordano, A. ;

Hughes, A. D. ;

Schini-Kerth, V. B. ;

Bronner, C. .

ONCOGENE, 2008, 27 (15) :2187-2197

[2] UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity [J].

Achour, Mayada ;

Fuhrmann, Guy ;

Alhosin, Mahmoud ;

Ronde, Philippe ;

Chataigneau, Thierry ;

Mousli, Marc ;

Schini-Kerth, Valerie B. ;

Bronner, Christian .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 390 (03) :523-528

[3] Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1 [J].

Alhosin, Mahmoud ;

Abusnina, Abdurazzag ;

Achour, Mayada ;

Sharif, Tanveer ;

Muller, Christian ;

Peluso, Jean ;

Chataigneau, Thierry ;

Lugnier, Claire ;

Schini-Kerth, Valerie B. ;

Bronner, Christian ;

Fuhrmann, Guy .

BIOCHEMICAL PHARMACOLOGY, 2010, 79 (09) :1251-1260

[4] Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase [J].

Allen, Mark D. ;

Grummitt, Charles G. ;

Hilcenko, Christine ;

Min, Sandra Young ;

Tonkin, Louise M. ;

Johnson, Christopher M. ;

Freund, Stefan M. ;

Bycroft, Mark ;

Warren, Alan J. .

EMBO JOURNAL, 2006, 25 (19) :4503-4512

[5] A review of known imprinting syndromes and their association with assisted reproduction technologies [J].

Amor, David J. ;

Halliday, Jane .

HUMAN REPRODUCTION, 2008, 23 (12) :2826-2834

[6] An unmethylated 3′ promoter-proximal region is required for efficient transcription initiation [J].

Appanah, Ruth ;

Dickerson, David R. ;

Goyal, Preeti ;

Groudine, Mark ;

Lorincz, Matthew C. .

PLOS GENETICS, 2007, 3 (02) :241-253

[7] Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism [J].

Arita, Kyohei ;

Ariyoshi, Mariko ;

Tochio, Hidehito ;

Nakamura, Yusuke ;

Shirakawa, Masahiro .

NATURE, 2008, 455 (7214) :818-U12

[8] Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1 [J].

Avvakumov, George V. ;

Walker, John R. ;

Xue, Sheng ;

Li, Yanjun ;

Duan, Shili ;

Bronner, Christian ;

Arrowsmith, Cheryl H. ;

Dhe-Paganon, Sirano .

NATURE, 2008, 455 (7214) :822-U13

[9] Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein [J].

Ayton, PM ;

Chen, EH ;

Cleary, ML .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (23) :10470-10478

[10] The complex language of chromatin regulation during transcription [J].

Berger, Shelley L. .

NATURE, 2007, 447 (7143) :407-412

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