Vascular types I and II transforming growth factor-beta receptor expression:: differential dependency on tyrosine kinases during induction by TGF-β

被引：8

作者：

Ward, MR

Agrotis, A

Jennings, G

Bobik, A

机构：

[1] Baker Med Res Inst, Cell Biol Lab, Prahran, Vic 3181, Australia

[2] Alfred Hosp, Prahran, Vic 3181, Australia

来源：

FEBS LETTERS | 1998年 / 422卷 / 02期

关键词：

transforming growth factor-beta; tyrosine kinase inhibition; transforming growth factor-beta receptor gene expression; vascular smooth muscle;

D O I：

10.1016/S0014-5793(98)00011-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent evidence indicates that the type II transforming growth factor-beta (TGF-beta) receptor (T beta RII) is a serine-threonine-tyrosine kinase. However, the significance of its tyrosine kinase is unclear. We investigated in vascular smooth muscle cells the effects of tyrosine kinase inhibition on the expression of TGF-beta receptor types I (ALK-5) and II (T beta RII) mRNA, induced by TGF-beta(1). TGF-beta(1) elevated ALK-5 mRNA levels 5-fold; essentially similar TGF-beta(1)-dependent elevations were observed,vith growth factors, PDGF-BB and FGF-2. The tyrosine kinase inhibitor genistein abolished these TGF-beta(1) and growth factor responses. TGF-beta(1) also elevated T beta RII mRNA levels which were not inhibited by genistein. We conclude that tyrosine kinases participate in defining how cells respond to TGF-beta. (C) 1998 Federation of European Biochemical Societies.

引用

页码：197 / 200

页数：4

共 30 条

[1] TRANSFORMING GROWTH FACTOR-BETA(1) GENE ACTIVATION AND GROWTH OF SMOOTH-MUSCLE FROM HYPERTENSIVE RATS [J].