Radiation-induced DNA double-strand breaks and the radiosensitivity of human cells: A closer look

被引:62
作者
Foray, N
Arlett, CF
Malaise, EP
机构
[1] Inst Gustave Roussy, Radiobiol Lab, URA CNRS 1967, PRI, F-94805 Villejuif, France
[2] Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1 9RR, E Sussex, England
关键词
human cells; radiosensitivity; DNA double-strand breaks; DNA repair;
D O I
10.1016/S0300-9084(97)82005-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A large number of reports suggest that DNA double-strand breaks (DSB) play a major role in the radiation-induce killing of mammalian cells. However, the arguments supporting the relationship between DSB and radiosensitivity are generally indirect. Furthermore, care must be taken to allow for the possible impact of the techniques and of the experimental protocols on the relationship between DSB and cell death. The recent data on DSB induction, repair and misrepair in human cell lines and their correlation with intrinsic radiosensitivity are reviewed.
引用
收藏
页码:567 / 575
页数:9
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