A novel asymmetric total synthesis of (+)-artemisinin

被引：41

作者：

Constantino, MG ^{[1
]}

Beltrame, M ^{[1
]}

daSilva, GVJ ^{[1
]}

机构：

[1] UNIV FED SAO CARLOS,DEPT QUIM,BR-13565905 SAO CARLOS,SP,BRAZIL

来源：

SYNTHETIC COMMUNICATIONS | 1996年 / 26卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1080/00397919608003621

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 12-step synthesis of the natural product (+)-Artemisinin, very active against malaria, is described. (-)-Isopulegol, which already contains two of the asymmetric centers of (+)-Artemisinin in the correct absolute configuration, was used as starting material.

引用

页码：321 / 329

页数：9

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