Mitochondria, oxygen free radicals, disease and ageing

被引:840
作者
Raha, S
Robinson, BH
机构
[1] Hosp Sick Children, Res Inst, Metab Res Programme, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Dept Biochem, Toronto, ON M5S 7AS, Canada
基金
英国医学研究理事会;
关键词
D O I
10.1016/S0968-0004(00)01674-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Superoxide is generated by the mitochondrial respiratory chain. The transformation of this superoxide into hydrogen peroxide and, under certain conditions, then into hydroxyl radicals is important in diseases where respiratory chain function is abnormal or where superoxide dismutase function is altered, as in amyotrophic lateral sclerosis. In additon, these reactive oxygen species can influence the ageing process through mechanisms involving mutagenesis of mtDNA or increased rates of shortening of telomeric DNA.
引用
收藏
页码:502 / 508
页数:7
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