Serum KL-6 in adult patients with polymyositis and dermatomyositis

被引：65

作者：

Kubo, M ^{[1
]}

Ihn, H ^{[1
]}

Yamane, K ^{[1
]}

Kikuchi, K ^{[1
]}

Yazawa, N ^{[1
]}

Soma, Y ^{[1
]}

Tamaki, K ^{[1
]}

机构：

[1] Univ Tokyo, Fac Med, Dept Dermatol, Bunkyo Ku, Tokyo 1138655, Japan

来源：

RHEUMATOLOGY | 2000年 / 39卷 / 06期

关键词：

ELISA; interstitial lung disease; internal malignancy;

D O I：

10.1093/rheumatology/39.6.632

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To determine the serum levels of KL-6, a mucin-like high-molecular-weight glycoprotein, in polymyositis/dermatomyositis (PM/DM) patients. Methods. Serum samples from 42 adult PM/DM patients and 38 healthy control subjects were examined using specific enzyme-linked immunosorbent assay (ELISA) systems. Results. The serum levels of KL-6 in the PM/DM patients were significantly higher than those of the healthy controls. The elevated serum KL-6 levels correlated with the presence of interstitial lung disease (ILD) and decreased percentage diffusing capacity of carbon monoxide (%DLco) in the PM/DM patients. The serum KL-6 levels inversely correlated with %DLco and percentage vital capacity. Additionally, the serum KL-6 levels were elevated in five of the seven DM patients with malignant neoplasia. Conclusions. These results suggest that the serum KL-6 level might be a useful serum marker for ILD and internal malignancy in PM/DM.

引用

页码：632 / 636

页数：5

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