Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease

被引：66

作者：

Sakurai, A ^{[1
]}

Okamoto, K

Fujita, Y

Nakazato, Y

Wakabayashi, K

Takahashi, H

Gonatas, NK

机构：

[1] Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan

[2] Gunma Univ, Sch Med, Dept Pathol, Maebashi, Gumma 3718511, Japan

[3] Niigata Univ, Inst Brain Res, Brain Dis Res Ctr, Niigata 9518585, Japan

[4] Niigata Univ, Inst Brain Res, Dept Pathol, Niigata 9518585, Japan

[5] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

ACTA NEUROPATHOLOGICA | 2000年 / 100卷 / 03期

关键词：

ballooned neuron; Golgi apparatus; corticobasal degeneration; Creutzfeldt-Jakob disease;

D O I：

10.1007/s004010000182

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated immunohistologically the Golgi apparatus (GA) and the trans-Golgi network (TGN) of the cortical ballooned neurons (BNs) in two patients with corticobasal degeneration and in five with Creutzfeldt-Jakob disease. We observed that the BNs showed fragmentation of the GA and the TGN, accompanied by a reduction in the number of fragmented Golgi elements and by a unique perinuclear distribution. This is the first report of the abnormalities of GA in cortical BNs. These findings suggests that the GA and the TGN may play some roles in the BN formation.

引用

页码：270 / 274

页数：5

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