Remembrance of things past: Maintaining gene expression patterns with altered chromatin

被引：25

作者：

Hagstrom, K ^{[1
]}

Schedl, P ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 06期

关键词：

D O I：

10.1016/S0959-437X(97)80045-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotic organisms have evolved mechanisms to stably preserve the gene expression patterns that determine cell fate. Recent advances have been made in understanding the DNA sequences and protein factors required to propagate gene activation or silencing. These studies suggest that, after gene activity states are selected during development, maintenance protein complexes provide a molecular memory of those states by altering a local domain of chromatin structure. (C) Current Biology Ltd ISSN 0959-437X.

引用

页码：814 / 821

页数：8

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