Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform

被引：538

作者：

Mulac-Jericevic, B ^{[1
]}

Mullinax, RA ^{[1
]}

DeMayo, FJ ^{[1
]}

Lydon, LP ^{[1
]}

Conneely, OM ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

SCIENCE | 2000年 / 289卷 / 5485期

关键词：

D O I：

10.1126/science.289.5485.1751

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Progesterone regulates reproductive function through two intracellular receptors, progesterone receptor-A (PR-A) and progesterone receptor-B (PR-B), that arise from a single gene and function as transcriptional regulators of progesterone-responsive genes. Although in vitro studies show that PR isoforms can display different transcriptional regulatory activities, their physiological significance is unknown. By selective ablation of PR-A in mice, we show that the PR-B isoform modulates a subset of reproductive functions of progesterone by regulation of a subset of progesterone-responsive target genes. Thus, PR-A and PR-B are functionally distinct mediators of progesterone action in vivo and should provide suitable targets for generation of tissue-selective progestins.

引用

页码：1751 / 1754

页数：4

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