Ca2+ channels as integrators of G protein-mediated signaling in neurons

被引：44

作者：

Strock, J ^{[1
]}

Diversé-Pierluissi, MA ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Dept Pharmacol & Biol Chem, New York, NY 10029 USA

来源：

MOLECULAR PHARMACOLOGY | 2004年 / 66卷 / 05期

关键词：

D O I：

10.1124/mol.104.002261

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The observations from Dunlap and Fischbach that transmitter-mediated shortening of the duration of action potentials could be caused by a decrease in calcium conductance led to numerous studies of the mechanisms of modulation of voltage-dependent calcium channels. Calcium channels are well known targets for inhibition by receptor-G protein pathways, and multiple forms of inhibition have been described. Inhibition of Ca2+ channels can be mediated by G protein betagamma-subunits or by kinases, such as protein kinase C and tyrosine kinases. In the last few years, it has been shown that integration of G protein signaling can take place at the level of the calcium channel by regulation of the interaction of the channel pore-forming subunit with different cellular proteins.

引用

页码：1071 / 1076

页数：6

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