Molecular mechanisms regulating myogenic determination and differentiation

被引:309
作者
Perry, RLS
Rudnicki, MA
机构
[1] McMaster Univ, Dept Biol, Hamilton, ON L8S 4K1, Canada
[2] McMaster Univ, Inst Mol Biol & Biotechnol, Hamilton, ON L8S 4K1, Canada
关键词
myogenesis; myogenic regulatory factors; gene targeting; development; myoblast; cell migration; satellite cell; stem cell; signal transduction; skeletal muscle; Review;
D O I
10.2741/Perry
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The myogenic regulatory factors are necessary for the determination and terminal differentiation of skeletal muscle. Gene targeting experiments have demonstrated that MyoD and Myf5 are important for myogenic determination whereas myogenin and MRF4 are important for terminal differentiation and lineage maintenance. During development, all trunk skeletal muscle is derived from the somite. Two spatially distinct sources of myogenic progenitors are defined by the expression of MyoD or Myf5 and these give rise to hypaxial and epaxial musculature. Both in vivo and in vitro analyses have provided a detailed picture regarding the molecular events controlling lineage determination, cell migration, terminal differentiation and tissue repair. Signal transduction pathways regulating cell cycle, protein-protein interactions and myogenic factor gene activation are implicated in the regulation of myogenesis. Recent experiments examining the origin and stem-cell capacity of satellite cells suggest that these cells may originate from the vascular system, are multipotential and may be useful for the treatment of several degenerative diseases.
引用
收藏
页码:D750 / D767
页数:18
相关论文
共 249 条
[1]   The importance of timing differentiation during limb muscle development [J].
Amthor, H ;
Christ, B ;
Weil, M ;
Patel, K .
CURRENT BIOLOGY, 1998, 8 (11) :642-652
[2]  
Amthor H, 1999, DEVELOPMENT, V126, P1041
[3]   Myogenin expression, cell cycle withdrawal, and phenotypic differentiation are temporally separable events that precede cell fusion upon myogenesis [J].
Andres, V ;
Walsh, K .
JOURNAL OF CELL BIOLOGY, 1996, 132 (04) :657-666
[4]  
AOYAMA H, 1988, DEVELOPMENT, V104, P15
[5]  
ARMAND O, 1983, ARCH ANAT MICROSC MO, V72, P163
[6]  
Arnold HH, 2000, CURR TOP DEV BIOL, V48, P129
[7]   Notch signaling: Cell fate control and signal integration in development [J].
Artavanis-Tsakonas, S ;
Rand, MD ;
Lake, RJ .
SCIENCE, 1999, 284 (5415) :770-776
[8]   THE REGULATION OF MYOD GENE-EXPRESSION - CONSERVED ELEMENTS MEDIATE EXPRESSION IN EMBRYONIC AXIAL MUSCLE [J].
ASAKURA, A ;
LYONS, GE ;
TAPSCOTT, SJ .
DEVELOPMENTAL BIOLOGY, 1995, 171 (02) :386-398
[9]   Apoptosis of epaxial myotome in Danforth's short-tail (SD) mice in somites that form following notochord degeneration [J].
Asakura, A ;
Tapscott, SJ .
DEVELOPMENTAL BIOLOGY, 1998, 203 (02) :276-289
[10]   The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD [J].
Bailey, P ;
Downes, M ;
Lau, P ;
Harris, J ;
Chen, SL ;
Hamamori, Y ;
Sartorelli, V ;
Muscat, GEO .
MOLECULAR ENDOCRINOLOGY, 1999, 13 (07) :1155-1168