Mouse brain organization revealed through direct genome-scale TF expression analysis

被引：344

作者：

Gray, PA

Fu, H

Luo, P

Zhao, Q

Yu, J

Ferrari, A

Tenzen, T

Yuk, DI

Tsung, EF

Cai, ZH

Alerta, JA

Cheng, LP

Liu, Y

Stenman, JM

Valerius, MT

Billings, N

Kim, HA

Greenberg, ME

McMahon, AP

Rowitch, DH

Stiles, CD ^{[1
]}

Ma, QF

机构：

[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[4] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[5] Childrens Hosp, Informat Program, Boston, MA 02115 USA

[6] Childrens Hosp, Div Newborn Med, Boston, MA 02115 USA

[7] Childrens Hosp, Div Neurosci, Boston, MA 02115 USA

来源：

SCIENCE | 2004年 / 306卷 / 5705期

关键词：

D O I：

10.1126/science.1104935

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the developing brain, transcription factors (TFs) direct the formation of a diverse array of neurons and glia. We identified 1445 putative TFs in the mouse genome. We used in situ hybridization to map the expression of over 1000 of these TFs and TF-coregulator genes in the brains of developing mice. We found that 349 of these genes showed restricted expression patterns that were adequate to describe the anatomical organization of the brain. We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database.

引用

页码：2255 / 2257

页数：3

共 18 条

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