New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-(5-halo)pyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine

被引：24

作者：

Levkovskaya, GG ^{[1
]}

Bozhenkov, GV ^{[1
]}

Larina, LI ^{[1
]}

Mirskova, AN ^{[1
]}

机构：

[1] Russian Acad Sci, Favorskii Irkutsk Inst Chem, Irkutsk 664033, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 38卷 / 10期

关键词：

Organic Chemistry; Ketone; Vinyl; Chloro; Halide;

D O I：

10.1023/A:1022564707537

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl(5-halo)pyrazoles. The reaction is accompanied by elimination of methyl halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.

引用

页码：1501 / 1506

页数：6

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