Cloning and characterization of the murine homologue of the rat/human MRC OX-2 gene

被引：27

作者：

Chen, Z

Zeng, H

Gorczynski, RM

机构：

[1] Univ Toronto, Toronto Hosp, Dept Surg, Transplant Res Div, Toronto, ON M5G 2C4, Canada

[2] Univ Toronto, Toronto Hosp, Dept Immunol, Transplant Res Div, Toronto, ON M5G 2C4, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1997年 / 1362卷 / 01期

关键词：

MRC OX-2; tolerance; immunoregulation; transplantation;

D O I：

10.1016/S0925-4439(97)00058-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 350bp amplicon, obtained by PCR-select subtractive hybridization from RNA derived from mesenteric lymph nodes (MLN) cells from mice pre-immunized with allogeneic lymphocytes 36hrs prior to receiving donor-specific skin grafts, and showing >98% homology with a published sequence for the rat MRC OX-2 gene, was used as a hybridization probe to screen a cDNA library constructed from adult mouse MLN treated in the same fashion. Several clones were identified which, on DNA sequence analysis, predicted a 218 amino acid protein showing significant homology with the rat and human MRC OX-2 gene product. (C) 1997 Elsevier Science B.V.

引用

页码：6 / 10

页数：5

共 22 条

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