The functions of thrombospondin-1 and-2

被引:374
作者
Lawler, J
机构
[1] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA 02215 USA
关键词
D O I
10.1016/S0955-0674(00)00143-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Considerable progress has been made towards understanding the function of thrombospondin-l and -2. The description of the phenotype of mice with thrombospondin-l and -2 knocked-out supports in vitro biochemical and cell-biological data and has opened new avenues of research. Recently, our understanding of the roles of thrombospondins in the activation of TG F beta, inhibition of angiogenesis and the initiation of signal transduction has advanced.
引用
收藏
页码:634 / 640
页数:7
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