Autoimmunity and β cell regeneration in mouse and human type 1 diabetes -: The peace is not enough

被引：37

作者：

Ablamunits, Vitaly ^{[1
]}

Sherry, Nicole A. ^{[1
]}

Kushner, Jake A. ^{[1
]}

Herold, Kevan C. ^{[1
]}

机构：

[1] Yale Univ, Dept Med, Immunol Sect, New Haven, CT 06520 USA

来源：

HOW DO WE BEST EMPLOY ANIMAL MODELS FOR TYPE 1 DIABETES AND MULTIPLE SCLEROSIS? | 2007年 / 1103卷

关键词：

immune therapy; type; 1; diabetes; beta cell regeneration;

D O I：

10.1196/annals.1394.006

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Accumulating data from animal models of type 1 diabetes and some findings from clinical studies suggest that autoimmune destruction of islet beta cells is associated with enhanced beta cell regeneration. Successful immune therapies, aimed at preservation of islet cell mass, result in a remarkable reduction of beta cell regeneration. Treated or not, as long as the task of treatment is limited by "making peace" with antoimmunity, the process of beta cell loss continues. Additional therapeutic modalities capable of stimulating beta cell regeneration in the absence of active autoimmune destruction are urgently needed.

引用

页码：19 / 32

页数：14

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