A microwave-assisted click chemistry synthesis of 1,4-disubstituted 1,2,3-triazoles via a copper(I)-catalyzed three-component reaction

被引：561

作者：

Appukkuttan, P

Dehaen, W

Fokin, VV

Van der Eycken, E

机构：

[1] Univ Louvain, Dept Chem, B-3001 Louvain, Belgium

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 23期

关键词：

D O I：

10.1021/ol048341v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A microwave-assisted three-component reaction was used to prepare a series of 1,4-disubstituted-1,2,3-triazoles from corresponding alkyl halides, sodium azide, and alkynes. This procedure eliminates the need to handle organic azides, as they are generated in situ, making this already powerful click process even more user-friendly and safe.

引用

页码：4223 / 4225

页数：3

共 27 条

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