The heat shock-induced cell cycle arrest is attenuated by weak electromagnetic fields

被引：17

作者：

Tokalov, SV ^{[1
]}

Gutzeit, HO ^{[1
]}

机构：

[1] Tech Univ Dresden, Inst Zool, D-01062 Dresden, Germany

来源：

CELL PROLIFERATION | 2003年 / 36卷 / 02期

关键词：

D O I：

10.1046/j.1365-2184.2003.00261.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stress-induced effects in human acute leukaemia cells (HL-60) were studied by flow cytometry using the fluorescent dye carboxyfluorescein succinimidyl ester which allows the analysis of several successive cell generations for up to 10 days. Asynchronously cycling cells subjected to heat shock (30 min at 41 degreesC) responded in two distinct ways: while one fraction of the cell population (about 15%) re-entered the cell cycle after a short delay, other cells became arrested at different phases of the cell cycle and remained arrested for up to several days and finally underwent apoptosis. Weak electromagnetic fields (60 muT, 50 Hz) alleviated the heat-induced block and the fraction of arrested cells was significantly smaller.

引用

页码：101 / 111

页数：11

共 51 条

[1]

Barnes JA, 2001, CELL STRESS CHAPERON, V6, P316, DOI 10.1379/1466-1268(2001)006<0316:EOIHET>2.0.CO

[2]

[3]

Carmody S, 2000, J CELL BIOCHEM, V79, P453, DOI 10.1002/1097-4644(20001201)79:3<453::AID-JCB100>3.0.CO

[4]

2-M

[5]

Chen YC, 1999, PHOTOCHEM PHOTOBIOL, V70, P78, DOI 10.1562/0031-8655(1999)070<0078:IOHSPA>2.3.CO

[6]

[7] DECAY OF THERMAL-RESISTANCE FOLLOWING ACUTE HEATING IS INDEPENDENT OF THE G1-PHASE TO S-PHASE TRANSITION [J].

COSS, RA .

RADIATION RESEARCH, 1986, 107 (01) :143-146

[8] Heat shock proteins: Facts, thoughts, and dreams [J].

De Maio, A .

SHOCK, 1999, 11 (01) :1-12

[9] Myocardial protection conferred by electromagnetic fields [J].

DiCarlo, AL ;

Farrell, JM ;

Litovitz, TA .

CIRCULATION, 1999, 99 (06) :813-816

[10]

FEBER M, 1999, ANNU REV PHYSIOL, V61, P243

← 1 2 3 4 5 6 →