Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells

被引：116

作者：

Kojima, H ^{[1
]}

Takeuchi, M ^{[1
]}

Ohta, T ^{[1
]}

Nishida, Y ^{[1
]}

Arai, N ^{[1
]}

Ikeda, M ^{[1
]}

Ikegami, H ^{[1
]}

Kurimoto, M ^{[1
]}

机构：

[1] Hayashibara Biochem Labs Inc, Fujisaki Inst, Okayama 702, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 244卷 / 01期

关键词：

D O I：

10.1006/bbrc.1998.8236

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pleiotropic biological activities of interleukin-18 (IL-18) are mediated by IL-18 receptor (IL-18R). When the ligand binds to the IL-18R, IL-18R initiates a signaling cascade that results in the activation of nuclear factor kappa B (NF-kappa B). When mouse EL-4 cells were exposed to IL-18, IL-1 receptor-associated kinase (IRAK) was recruited to IL-18R and was phosphorylated. In addition, tumor necrosis factor receptor-associated factor-6 (TRAF6) was associated with IRAK. Therefore, we concluded that IL-18/IL-18R-mediated signaling may share the IRAK/TRAF6 pathway through NF-KB activation with the IL-1/IL-1 receptor system. (C) 1998 Academic Press.

引用

页码：183 / 186

页数：4

共 22 条

[1] TARF6 is a signal transducer for interleukin-1
Cao, ZD
Xiong, J
Takeuchi, M
Kurama, T
Goeddel, DV
[J]. NATURE, 1996, 383 (6599) : 443 - 446
[2] IRAK: A kinase associated with the interleukin-1 receptor
Cao, ZD
Henzel, WJ
Gao, XO
[J]. SCIENCE, 1996, 271 (5252) : 1128 - 1131
[3] NF-KAPPA-B ACTIVATION BY INTERLEUKIN-1 (IL-1) REQUIRES AN IL-1 RECEPTOR-ASSOCIATED PROTEIN-KINASE ACTIVITY
CROSTON, GE
CAO, ZD
GOEDDEL, DV
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (28) : 16514 - 16517
[4] Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells
Dao, T
Ohashi, K
Kayano, T
Kurimoto, M
Okamura, H
[J]. CELLULAR IMMUNOLOGY, 1996, 173 (02) : 230 - 235
[5] A cytokine-responsive I kappa B kinase that activates the transcription factor NF-kappa B
DiDonato, JA
Hayakawa, M
Rothwarf, DM
Zandi, E
Karin, M
[J]. NATURE, 1997, 388 (6642) : 548 - 554
[6] Biologic basis for interleukin-1 in disease
Dinarello, CA
[J]. BLOOD, 1996, 87 (06) : 2095 - 2147
[7] CONTRASTING EFFECTS OF THE PROTEIN-KINASE-C INHIBITOR STAUROSPORINE ON THE INTERLEUKIN-1 AND PHORBOL ESTER ACTIVATION PATHWAYS IN THE EL4-6.1 THYMOMA CELL-LINE
DORNAND, J
BOUABOULA, M
DANGEAC, AD
FAVERO, J
SHIRE, D
CASELLAS, P
[J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1992, 151 (01) : 71 - 80
[8] HEGUY A, 1992, J BIOL CHEM, V267, P2605
[9] MAP3K-related kinase involved in NF-kappa B induction by TNF, CD95 and IL-1
Malinin, NL
Boldin, MP
Kovalenko, AV
Wallach, D
[J]. NATURE, 1997, 385 (6616) : 540 - 544
[10] Interleukin-18 activates NF-kappa B in murine T helper type 1 cells
Matsumoto, S
TsujiTakayama, K
Aizawa, Y
Koide, K
Takeuchi, M
Ohta, T
Kurimoto, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 234 (02) : 454 - 457

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