An oxidative phenol coupling reaction catalyzed by OxyB, a cytochrome p450 from the vancomycin-producing microorganism

被引：107

作者：

Zerbe, K ^{[1
]}

Woithe, K ^{[1
]}

Li, DB ^{[1
]}

Vitali, F ^{[1
]}

Bigler, L ^{[1
]}

Robinson, JA ^{[1
]}

机构：

[1] Univ Zurich, Inst Organ Chem, CH-8057 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 48期

关键词：

antibiotics; biosynthesis; enzymes; glycopeptides; natural products;

D O I：

10.1002/anie.200461278

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

During the biosynthesis of glycopeptide antibiotics of the vancomycin family, several oxidative phenol coupling reactions take place. An oxygenase (OxyB) from the vancomycin producer catalyzes the first of these coupling reactions to a significant extent only when the putative hexapeptide substrate is linked as a thioester to a peptide carrier domain (PCD) derived from the non-ribosomal peptide synthetase (see picture).

引用

页码：6709 / 6713

页数：5

共 23 条

[1] Bischoff D, 2001, ANGEW CHEM INT EDIT, V40, P4688, DOI 10.1002/1521-3773(20011217)40:24<4688::AID-ANIE4688>3.0.CO
[2] 2-M
[3] Bischoff D, 2001, ANGEW CHEM INT EDIT, V40, P1693, DOI 10.1002/1521-3773(20010504)40:9<1693::AID-ANIE16930>3.0.CO
[4] 2-8
[5] Bischoff D., 2001, ANGEW CHEM, V113, P4824
[6] BISCHOFF D, 2004, IN PRESS CHEMBIOCHEM
[7] Bischoff D., 2001, ANGEW CHEM, V113, P1736
[8] Freund E, 2000, HELV CHIM ACTA, V83, P2572, DOI 10.1002/1522-2675(20000906)83:9<2572::AID-HLCA2572>3.0.CO
[9] 2-X
[10] The tyrocidine biosynthesis operon of Bacillus brevis: Complete nucleotide sequence and biochemical characterization of functional internal adenylation domains
Mootz, HD
Marahiel, MA
[J]. JOURNAL OF BACTERIOLOGY, 1997, 179 (21) : 6843 - 6850

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