Determination of tricyclic antidepressants using a carbon paste electrode modified with β-cyclodextrin

被引：74

作者：

Ferancová, A ^{[1
]}

Korgová, E ^{[1
]}

Mikó, R ^{[1
]}

Labuda, J ^{[1
]}

机构：

[1] Slovak Univ Technol Bratislava, Dept Analyt Chem, Bratislava 81237, Slovakia

来源：

JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 2000年 / 492卷 / 01期

关键词：

antidepressant drugs; biosensor; chemically modified electrode; cyclodextrin; DP voltammetry;

D O I：

10.1016/S0022-0728(00)00237-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Carbon paste electrodes modified with beta -cyclodextrin have been investigated for the DP voltammetric determination of the tricyclic antidepressants - imipramine, trimipramine and thioridazine. Host-guest interaction was studied and experimental conditions of the working procedure were optimized. The accumulation ability of beta -cyclodextrin leads to detection limits down to nanomolar concentrations for 120 s accumulation. The electrode was applied to the determination of imipramine and thioridazine in pharmaceuticals. (C) 2000 Elsevier Science B.V. All rights resented.

引用

页码：74 / 77

页数：4

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