Low detection rate of HPV in oral and laryngeal carcinomas

被引:37
作者
Matzow, T
Boysen, M
Kalantari, M
Johansson, B
Hagmar, B [1 ]
机构
[1] Natl Hosp Norway, Dept Pathol, N-0027 Oslo, Norway
[2] Natl Hosp Norway, Dept ENT, N-0027 Oslo, Norway
[3] Huddinge Univ Hosp, Dept Clin Virol, S-14186 Huddinge, Sweden
关键词
D O I
10.1080/028418698423203
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The presence of human papillomaviruses (HPVs) in 38 oral and 16 laryngeal lesions (verrucous hyperplasia, carcinoma in situ and carcinomas) was investigated using the polymerase chain reaction (PCR) technique. All biopsies were fresh frozen and a set of consensus and type-specific primers was used for PCR detection and HPV typing. In oral biopsies a low proportion of HPV-positive cases was found. despite the sensitive techniques. Only one case out of 38, a carcinoma in situ was positive (2.6%). Tt is thought that this finding reflects a minimal presence of HPV in the oral lesions, but a transient role of virus in the induction of carcinomas cannot be ruled out. Differences in relation to other studies may be geographical and/or methodological. In laryngeal carcinomas (and dysplasias), 3 out of 16 cases were HPV positive. This frequency (19%) concurs with most other studies.
引用
收藏
页码:73 / 76
页数:4
相关论文
共 32 条
[1]  
ANDERSON JA, 1994, ARCH OTOLARYNGOL, V120, P755
[2]  
[Anonymous], IARC MON EV CARC RIS
[3]   AMPLIFICATION OF HUMAN PAPILLOMAVIRUS TYPE-16 AND TYPE-18 IN INVASIVE CERVICAL-CANCER [J].
BERUMEN, J ;
UNGER, ER ;
CASAS, L ;
FIGUEROA, P .
HUMAN PATHOLOGY, 1995, 26 (06) :676-681
[4]  
BRANDWEIN M, 1994, MODERN PATHOL, V7, P720
[5]   ANALYSIS OF PREVALENCE OF HUMAN PAPILLOMAVIRUS IN LARYNGEAL CARCINOMAS - STUDY OF 40 CASES USING POLYMERASE CHAIN-REACTION AND CONSENSUS PRIMERS [J].
BRANDWEIN, MS ;
NUOVO, GJ ;
BILLER, H .
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1993, 102 (04) :309-313
[6]  
CHANG F, 1990, ARCH DERMATOL RES, V282, P57
[7]  
Chiba I, 1996, ONCOGENE, V12, P1663
[8]   ANALYSIS BY POLYMERASE CHAIN-REACTION OF THE PHYSICAL STATE OF HUMAN PAPILLOMAVIRUS TYPE-16 DNA IN CERVICAL PRENEOPLASTIC AND NEOPLASTIC LESIONS [J].
DAS, BC ;
SHARMA, JK ;
GOPALAKRISHNA, V ;
LUTHRA, UK .
JOURNAL OF GENERAL VIROLOGY, 1992, 73 :2327-2336
[9]   HUMAN PAPILLOMAVIRUS INFECTION IN THE MALIGNANT AND PREMALIGNANT HEAD AND NECK EPITHELIUM [J].
FOURET, P ;
MARTIN, F ;
FLAHAULT, A ;
SAINTGUILY, JL .
DIAGNOSTIC MOLECULAR PATHOLOGY, 1995, 4 (02) :122-127
[10]   HUMAN PAPILLOMAVIRUSES IN THE PATHOGENESIS OF ANOGENITAL CANCER [J].
HAUSEN, HZ .
VIROLOGY, 1991, 184 (01) :9-13