Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: Discovery of a new leucine-rich nuclear export signal site

被引：25

作者：

Fukasawa, Masashi ^{[1
]}

Ge, Qing ^{[1
]}

Wynn, R. Max ^{[1
]}

Ishii, Seiji ^{[1
]}

Uyeda, Kosaku ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA

[2] Dallas Vet Affairs Med Ctr, Dallas, TX 75216 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 391卷 / 02期

关键词：

Carbohydrate responsive element binding protein; Nuclear import/export signal sites; Lipogenesis; Transcription factor; Glucose signals and 14-3-3; TRANSCRIPTION FACTOR; GLUCOSE; GENE; REGION; RANGTP; CRM1; MLX;

D O I：

10.1016/j.bbrc.2009.11.115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carbohydrate response element binding protein (ChREBP) is responsible for conversion of dietary carbohydrate to storage fat in liver by coordinating expression of the enzymes that channel glycolytic pyruvate into lipogenesis. The activation of ChREBP in response to high glucose is nuclear localization and transcription, and the inactivation of ChREBP under low glucose involves export from the nucleus to the cytosol. Here we report a new nuclear export signal site ("NES1") of ChREBP. Together these signals provide ChREBP with two NES sequences, both the previously reported NES2 and now the new NES1 coordinate to interact together with CRM1 (exportin) for nuclear export of the carbohydrate response element binding protein. Published by Elsevier Inc.

引用

页码：1166 / 1169

页数：4

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