Protein A - a new ligand for human C-reactive protein

被引：10

作者：

Das, T

Mandal, C

机构：

[1] Indian Inst Chem Biol, Immunobiol Div, Kolkata 700032, W Bengal, India

[2] Indian Inst Chem Biol, Drug Design Dev & Mol Modelling Div, Kolkata 700032, W Bengal, India

来源：

FEBS LETTERS | 2004年 / 576卷 / 1-2期

关键词：

C center dot reactive protein; glycosylated human C-reactive protein; molecular variant; phosphorylcholine; protein A binding; Staphylococcus aureus cell-surface protein A;

D O I：

10.1016/j.febslet.2004.08.072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorylcholine (PC) is a classical ligand of C-reactive protein (CRP), a clinically important acute phase protein. In search of new ligands, CRPs were affinity-purified from several pathological samples, which exhibited distinct molecular variants induced in different diseases. Both glycosylated and non-glycosylated CRPs showed calcium-independent differential-binding to Staphylococcus aureus cell-surface Protein A. CRP possesses separate binding sites for Protein A and PC with different binding constants. We have demonstrated that Protein A is another ligand in addition to PC establishing an extended definition of CRP. Protein A binding may impart immunomodulatory roles of CRP in combating microorganisms or other foreign materials. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B V. All rights reserved.

引用

页码：107 / 113

页数：7

共 23 条

[1] Induction of glycosylation in human C-reactive protein under different pathological conditions [J].