Mycobacterial Hand Infections Occurring Postoperatively in Patients Treated With Tumor Necrosis Factor-α Inhibitors for Inflammatory Arthritis: Report of Three Cases

被引：8

作者：

Bauer, Andrea S. ^{[1
]}

Blazar, Philip E. ^{[1
]}

Earp, Brandon E. ^{[1
]}

Simmons, Barry P. ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Dept Orthoped, Div Hand Surg, Boston, MA 02115 USA

来源：

JOURNAL OF HAND SURGERY-AMERICAN VOLUME | 2010年 / 35A卷 / 01期

关键词：

Hand infections; mycobacteria; TNF-alpha inhibitors; SURGICAL-SITE INFECTIONS; RHEUMATOID-ARTHRITIS; ORTHOPEDIC-SURGERY; RISK-FACTORS; COMPLICATIONS; METHOTREXATE; FREQUENCY;

D O I：

10.1016/j.jhsa.2009.09.018

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Tumor necrosis factor-alpha inhibitors are potent anti-rheumatic drugs, but there is evidence that the high level of immunosuppression they provide may also lead to a higher risk of infections. At our institution, 3 patients with inflammatory arthritis treated with tumor necrosis factor-alpha inhibitors developed mycobacterial soft tissue infections after routine hand surgery. All 3 patients required multiple surgical procedures, inpatient hospitalizations, and prolonged antibiotic multidrug therapy to clear the infections. (J Hand Surg 2010;35A:104-108. (C) 2010 Published by Elsevier Inc. on behalf of the American Society for Surgery of the Hand.)

引用

页码：104 / 108

页数：5

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