Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study

被引：15

作者：

Reulen, R. C. ^{[1
]}

Zeegers, M. P.

Lancashire, E. R.

Winter, D. L.

Hawkins, M. M.

机构：

[1] Univ Birmingham, Ctr Childhood Canc Survivor Studies, Dept Epidemiol & Publ Hlth, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Unit Genet Epidemiol, Dept Epidemiol & Publ Hlth, Birmingham B15 2TT, W Midlands, England

[3] Catholic Univ Louvain, Inst Comprehens Canc Limburg, Dept Gen Practice, B-3000 Louvain, Belgium

来源：

BRITISH JOURNAL OF CANCER | 2007年 / 96卷 / 09期

关键词：

radiation; sex ratio; childhood cancer survivors; epidemiology;

D O I：

10.1038/sj.bjc.6603736

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated offspring sex ratio among 6232 offspring born to 3218 survivors of childhood cancer in relation to therapeutic irradiation, and pooled our data with those from two other large-scale studies giving a total of 9685 offspring. Exposure to high-dose gonadal irradiation was not associated with a significant alteration in offspring sex ratio compared to low doses (men: P=0.58, women: P=0.66). There was also no evidence that the ratio varied with time since cancer diagnosis when comparing survivors treated with radiotherapy vs those without ( men: P=0.51; women: P=0.46). This, the largest study to date, finds no evidence that exposure to radiation affects the offspring sex ratio among survivors of childhood cancer.

引用

页码：1439 / 1441

页数：3

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