Pharmacologic loading in the treatment of acute mania

被引：13

作者：

Keck, PE

McElroy, SL

Bennett, JA

机构：

[1] Univ Cincinnati, Coll Med, Dept Psychiat, Biol Psychiat Program, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Coll Pharm, Cincinnati, OH 45267 USA

来源：

BIPOLAR DISORDERS | 2000年 / 2卷 / 01期

关键词：

carbamazepine; lithium; manic symptoms; pharmacokinetics; valproate;

D O I：

10.1034/j.1399-5618.2000.020106.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The rapid and safe reduction of manic symptoms is an important initial goal of the pharmacologic treatment of acute mania. The pharmacokinetics and studies of pharmacologic loading of lithium, valproate, and carbamazepine were reviewed. In addition, the feasibility of administering other agents with potential efficacy in mania, e.g., atypical antipsychotics and new anticonvulsants, was discussed. Further double-blind, controlled studies with adequate sample sizes comparing loading strategies with more gradual titration schedules of candidate antimanic agents are needed.

引用

页码：42 / 46

页数：5

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