Bladder neck mobility is a heritable trait

被引:60
作者
Dietz, HP
Hansell, NK
Grace, ME
Eldridge, AM
Clarke, B
Martin, NG
机构
[1] Univ Sydney, Sydney, NSW 2006, Australia
[2] Queensland Inst Med Res, Brisbane, Qld 4006, Australia
[3] Royal Hosp Women, Brisbane, Qld, Australia
关键词
D O I
10.1111/j.1471-0528.2004.00428.x
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective Congenital connective tissue dysfunction may partly be responsible for female pelvic organ prolapse and urinary incontinence. We undertook a heritability study to determine whether mobility of the bladder neck, one of the main determinants of stress urinary incontinence, is genetically influenced. Design Heritability study using a twin model and structural equation modelling. Setting Queensland Institute of Medical Research, Brisbane, Australia. Population One hundred and seventy-eight nulliparous Caucasian female twins and their sisters (46 monozygotic pairs, 24 dizygotic pairs and 38 sisters) aged 18 - 24 years. Methods We performed translabial ultrasound, supine and after bladder emptying, for pelvic organ mobility. Urethral rotation and bladder neck descent were calculated using the best of three effective Valsalva manoeuvres. Main outcome measures Bladder and urethral mobility on Valsalva assessed by urethral rotation, vertical and oblique bladder neck descent. Results Genetic modelling indicated that additive genes accounted for up to 59% of the variance for bladder neck descent. All remaining variance appeared due to environmental influences unique to the individual, including measurement error. Conclusion A significant genetic contribution to the phenotype of bladder neck mobility appears likely.
引用
收藏
页码:334 / 339
页数:6
相关论文
共 26 条
[1]  
Balmforth J., 2003, Neurourology and Urodynamics, V22, P540
[2]  
CARLEY ME, 1995, INT UROGYNECOL J PEL, V10, P65
[3]   Reproductive factors, family history, occupation and risk of urogenital prolapse [J].
Chiaffarino, F ;
Chatenoud, L ;
Dindelli, M ;
Meschia, M ;
Buonaguidi, A ;
Amicarelli, F ;
Surace, M ;
Bertola, E ;
Di Cintio, E ;
Parazzini, F .
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1999, 82 (01) :63-67
[4]   Ultrasound imaging of the pelvic floor. Part II: three-dimensional or volume imaging [J].
Dietz, HP .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2004, 23 (06) :615-625
[5]   Ultrasound imaging of the pelvic floor. Part I: two-dimensional aspects [J].
Dietz, HP .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2004, 23 (01) :80-92
[6]   The effect of childbirth on pelvic organ mobility [J].
Dietz, HP ;
Bennett, MJ .
OBSTETRICS AND GYNECOLOGY, 2003, 102 (02) :223-228
[7]   Antenatal pelvic organ mobility is associated with delivery mode [J].
Dietz, HP ;
Moore, KH ;
Steensma, AB .
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 2003, 43 (01) :70-74
[8]   Bladder neck mobility and urethral closure pressure as predictors of genuine stress incontinence [J].
Dietz, HP ;
Clarke, B ;
Herbison, P .
INTERNATIONAL UROGYNECOLOGY JOURNAL, 2002, 13 (05) :289-293
[9]   Ultrasound in the quantification of female pelvic organ prolapse [J].
Dietz, HP ;
Haylen, BT ;
Broome, J .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2001, 18 (05) :511-514
[10]  
DIETZ HP, IN PRESS AM J OBSTET