Merocyanine dyes with improved photostability

被引：81

作者：

Toutchkine, Alexei

Nguyen, Dan-Vinh

Hahn, Klaus M.

机构：

[1] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Canc Ctr, Chapel Hill, NC 27599 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 15期

关键词：

D O I：

10.1021/ol070780h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Merocyanine dyes have proven valuable for live cell fluorescence imaging applications, but many structures have been limited by rapid photobleaching. We show that photostability is substantially enhanced for merocyanines having a cyano group at a specific position in the central polymethine chain. Evidence is presented that this is due to reduction in reactivity of the dyes with singlet oxygen. These results point toward cyano-substitution as a general strategy for improving dye performance in imaging applications.

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页码：2775 / 2777

页数：3

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