Mechanisms of enhanced prevalence of asthma and atopy in developed countries

被引：73

作者：

Hopkin, JM ^{[1
]}

机构：

[1] Churchill Hosp, Osler Chest Unit, Lung Res Lab, Oxford OX3 7LJ, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(97)80179-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atopy - a T helper 2 cell driven hypersensitivity to innocuous antigens (allergens) which causes most cases of asthma - is of complex genetic and environmental origins. There is compelling epidemiological evidence for a rise in atopic disease in 'westernised' communities. The changing pattern of microbial exposure in early childhood is suggested to be the principal candidate mechanism for this rise.

引用

页码：788 / 792

页数：5

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