Rapid access to enantiopure bupropion and its major metabolite by stereospecific nucleophilic substitution on an α-ketotriflate

被引：85

作者：

Fang, QK ^{[1
]}

Han, ZX ^{[1
]}

Grover, P ^{[1
]}

Kessler, D ^{[1
]}

Senanayake, CH ^{[1
]}

Wald, SA ^{[1
]}

机构：

[1] Sepracor Inc, Chem Proc Res & Dev, Marlborough, MA 01752 USA

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 18期

关键词：

D O I：

10.1016/S0957-4166(00)00349-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A stereospecific method for the synthesis of enantiopure alpha -aminoketone from its corresponding alpha -hydroxy-ketone via the triflate intermediate is discussed. This strategy provides a rapid and efficient route for the preparation of either enantiomer of bupropion and its biologically active hydroxylated metabolite, (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3659 / 3663

页数：5

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