Structural correlates of apathy in Alzheimer's disease

被引：133

作者：

Apostolova, Liana G.

Akopyan, Gohar G.

Partiali, Negar

Steiner, Calen A.

Dutton, Rebecca A.

Hayashi, Kiralee M.

Dinov, Ivo D.

Toga, Arthur W.

Cummings, Jeffrey L.

Thompson, Paul M.

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Lab Neuro Imaging, Los Angeles, CA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Stat, Los Angeles, CA USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2007年 / 24卷 / 02期

关键词：

apathy; Alzheimer's disease; neuropsychiatric inventory; cingulate gyrus; atrophy;

D O I：

10.1159/000103914

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: Apathy is the most common noncognitive symptom in Alzheimer's disease ( AD). The structural correlates of apathy in AD have not yet been described. Methods: We analyzed magnetic resonance imaging data of 35 AD patients with and without apathy. Results: There was a significant linear association between apathy severity and cortical gray matter atrophy in the bilateral anterior cingulate [ Brodmann area ( BA) 24; r = 0.39 - 0.42, p = 0.01] and left medial frontal cortex ( BA 8 and 9; r = 0.4, p < 0.02). Left mean cingulate cortical thinning predicted the presence/absence of apathy at the trend level of significance. Conclusion: Our study demonstrates a strong association between apathy and the integrity of medial frontal regions in AD. Copyright (c) 2007 S. Karger AG, Basel.

引用

页码：91 / 97

页数：7

共 31 条

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