Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis

被引：52

作者：

Benedek, Gil ^{[1
,2
]}

Zhang, Jun ^{[1
,2
]}

Bodhankar, Sheetal ^{[1
,2
]}

Ha Nguyen ^{[1
,2
]}

Kent, Gail ^{[1
,2
]}

Jordan, Kelley ^{[1
,2
]}

Manning, Dustin ^{[1
,2
]}

Vandenbark, Arthur A. ^{[1
,2
,3
]}

Offner, Halina ^{[1
,2
,4
]}

机构：

[1] VA Portland Hlth Care Syst, Neuroimmunol Res, 3710 SW US Vet Hosp Rd, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Neurol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[3] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[4] Oregon Hlth & Sci Univ, Dept Anesthesiol & Perioperat Med, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 293卷

关键词：

Estrogen; EAE; Regulatory B cell; Microglia; IL-10; IFN-gamma; DEFICIENT MICE; T-CELLS; ALTERNATIVE ACTIVATION; CNS REMYELINATION; SEX-DIFFERENCES; RECEPTOR-ALPHA; SCLEROSIS; INFLAMMATION; MACROPHAGES; INDUCTION;

D O I：

10.1016/j.jneuroim.2016.02.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sex hormones promote immunoregulatory effects on multiple sclerosis. The current study evaluated estrogen effects on regulatory B cells and resident CNS microglia during experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen-dependent induction of multiple regulatory B cell markers indicative of IL-10 dependent as well as IFN-gamma dependent pathways. Moreover, although estrogen pretreatment of EAE mice inhibited the infiltration of pro-inflammatory cells into the CNS, it enhanced the frequency of regulatory B cells and M2 microglia. Our study suggests that estrogen has a broad effect on the development of regulatory B cells during EAE, which in turn could promote neuroprotection. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：45 / 53

页数：9

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[1] Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains [J].