Histone H3 lysine 4 (H3K4) methylation in development and differentiation

被引：232

作者：

Eissenberg, Joel C. ^{[1
]}

Shilatifard, Ali ^{[2
]}

机构：

[1] St Louis Univ, Sch Med, Edward A Doisy Dept Biochem & Mol Biol, St Louis, MO 63104 USA

[2] Stowers Inst Med Res, Kansas City, MO 64110 USA

来源：

DEVELOPMENTAL BIOLOGY | 2010年 / 339卷 / 02期

关键词：

Histone methylation; Trithorax; SET domain; Compass complex; MLL; HOX genes; TRITHORAX-GROUP PROTEIN; H3-LYS(4) METHYLTRANSFERASE COMPLEX; LITTLE-IMAGINAL-DISCS; SHOCK GENE-EXPRESSION; SET-DOMAIN PROTEINS; RNA-POLYMERASE-II; DROSOPHILA-TRITHORAX; CHROMATIN-STRUCTURE; ACUTE LEUKEMIAS; ACTIVE GENES;

D O I：

10.1016/j.ydbio.2009.08.017

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Covalent modification of histones on chromatin is a dynamic mechanism by which various nuclear processes are regulated. Methylation of histone H3 on lysine 4 (H3K4) implemented by the macromolecular complex COMPASS and its related complexes is associated with transcriptionally active regions of chromatin. Enzymes that catalyze H3K4 methylation were initially characterized genetically as regulators of Hox loci, long before their catalytic functions were recognized. Since their discovery, genetic and biochemical studies of H3K4 methylases and demethylases have provided important mechanistic insight into the role of H3K4 methylation in HOX gene regulation during development. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：240 / 249

页数：10

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