In vivo magnetic resonance spectroscopy of human brain: The biophysical basis of dementia

被引：70

作者：

Ross, BD ^{[1
]}

Bluml, S ^{[1
]}

Cowan, R ^{[1
]}

Danielsen, E ^{[1
]}

Farrow, N ^{[1
]}

Gruetter, R ^{[1
]}

机构：

[1] Huntington Med Res Inst, Pasadena, CA 91105 USA

来源：

BIOPHYSICAL CHEMISTRY | 1997年 / 68卷 / 1-3期

关键词：

nuclear magnetic resonance spectroscopy; neuronal markers; neurochemistry disorders; Alzheimer disease; neurotransmitters;

D O I：

10.1016/S0301-4622(97)00032-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear magnetic resonance spectroscopy (MRS) in low and medium magnetic fields yields well-resolved natural abundance proton and decoupled phosphorus spectra from small (1-10 cc) volumes of brain in vivo in minutes. With this tool, neurochemical research has advanced through identification and non-invasive assay of specific neuronal - (N-acetylaspartate), glial (myo-inositol) - markers, energetics and osmolytes, and neurotransmitters (glutamate, GABA), From these simple measurements, several dozen disease states are recognized, including birth injury, and white matter and Alzheimer disease. Addition of stable isotopes of carbon (in man) or nitrogen (in experimental animals) has provided in vivo assays of enzyme flux through glucose transport, glycolysis, TCA-cycle, and the glutamine-glutamate-GABA system. Finally, a number of xenobiotics are recognized with heteronuclear NMR techniques. Together, these tools are having a major impact on neuroscience and clinical medicine. Through diagnosis and therapeutic monitoring, a new generation of in vivo metabolite imaging is expected with the advent of conforming RF coils and higher field NMR systems. (C) 1997 Elsevier Science B.V.

引用

页码：161 / 172

页数：12

共 65 条

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