Performance of the Abbott RealTime High-Risk HPV Test in Women With Abnormal Cervical Cytology Smears

被引：29

作者：

Cuzick, Jack ^{[1
]}

Ambroisine, Laurence ^{[1
]}

Cadman, Louise ^{[1
]}

Austin, Janet ^{[1
]}

Ho, Linda ^{[1
]}

Terry, George ^{[1
]}

Liddle, Stuart ^{[2
]}

Dina, Roberto ^{[3
,4
]}

McCarthy, Julie ^{[5
]}

Buckley, Hilary ^{[6
]}

Bergeron, Christine ^{[7
]}

Soutter, W. P. ^{[8
,9
]}

Lyons, Deirdre

Szarewski, Anne ^{[1
]}

机构：

[1] Queen Mary Univ London, Wolfson Inst Prevent Med, Canc Res UK Ctr Epidemiol Math & Stat, London EC1M 6BQ, England

[2] Doctors Lab, London, England

[3] Hammersmith Hosp, Dept Cytopathol, London, England

[4] Queen Charlottes & Chelsea Hosp, Dept Cytopathol, London W6 0XG, England

[5] St Marys Hosp, Dept Cytopathol, London, England

[6] St Marys Hosp, Dept Pathol, Manchester M13 0JH, Lancs, England

[7] Lab Pasteur Cerba, Cergy Pontoise 9, France

[8] Hammersmith Hosp, Dept Gynaecol, London, England

[9] Queen Charlottes & Chelsea Hosp, Dept Gynaecol, London W6 0XG, England

来源：

JOURNAL OF MEDICAL VIROLOGY | 2010年 / 82卷 / 07期

关键词：

HPV testing; cervical screening; Abbott RealTime high-risk HPV test; sensitivity; specificity; HUMAN-PAPILLOMAVIRUS DNA; INTRAEPITHELIAL NEOPLASIA; CONVENTIONAL CYTOLOGY; FOLLOW-UP; CANCER;

D O I：

10.1002/jmv.21801

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HPV DNA testing is known to be much more sensitive than cytology, but less specific. A range of HPV and related tests in 858 women referred for colposcopy because of an abnormal smear were evaluated to compare the performances of these tests. This article compared the Abbott test to other tests which had been previously evaluated. This test was a real true test for 14 high-risk HPV types. The Abbott test was found to be highly sensitive for cervical intra-epithelial neoplasia grade 3 or worse (CIN3+) (98.9%) with a specificity of 31.5%. These numbers were comparable with the Qiagen HC2 test, the Roche Linear Array and Amplicor tests, and the Gen-Probe APTI MA test. Differences between these tests appeared to be related mostly to the choice of cutoff level. An added feature of the Abbott test was the provision of type specific results for HPV 16 and 18. J. Med. Virol. 82:1186-1191,2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：1186 / 1191

页数：6

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